Establishing a customer relationship management between the broadcaster and the digital user

As the consumer is becoming digital - i.e. he has personal mobile and always internet-connected devices allowing him to create a digital footprint anytime, anywhere - new opportunities arise for the ldquoclassicrdquo broadcast industry to set up and maintain a direct relationship with their TV-viewers and radio-listeners. Until recently, a broadcaster had a one way connection with its customers, namely from the broadcaster, over the TV and radio distribution channel to the physical TV screen or radio set. Interaction was only possible after implementing and deploying expensive and hard-to-develop software on the set-top box. By employing web technology intelligently, a broadcaster can now more easily connect to its consumers and build a direct relationship. In this paper, we will discuss how to set up such a system and what the particular needs are in a broadcast context. We will use the second screen to collect data and enrich it in order to become beneficial information for the broadcasters and the advertisers

Incidence, prevention and management of anti-drug antibodies against therapeutic antibodies in inflammatory bowel disease : a practical overview

The introduction of biologic therapy has revolutionized the treatment of inflammatory bowel disease (IBD). However, like all therapeutic proteins, monoclonal antibodies have immunogenic potential which is influenced by multiple drug- and patient-related factors. The reported incidence of anti-drug antibodies (ADAs) towards biologic drugs in IBD varies greatly in the literature and depends not only on differences in sensitization but also on the assaymethodology and the timepoint of measurement. Sensitization with formation of ADAsis associated with an increased risk of infusion reactions, accelerated drug clearance, and a loss of response (LOR) to drug. Recently, a greater understanding of the pharmacokinetics of therapeutic antibodies has led to the development of new strategies to reduce immunogenicity and more efficient use of these drugs. These preventive strategies include regular scheduled dosing with maintenance of stable therapeutic trough drug concentrations, and co-administration of an immunosuppressive. Sub-therapeutic drug concentrations with escalation, whereas the presence of high concentrations of ADAs requires a switch to another therapeutic agent

Establishing a customer relationship management between the broadcaster and the digital user

As the consumer is becoming digital - i.e. he has personal mobile and always internet-connected devices allowing him to create a digital footprint anytime, anywhere - new opportunities arise for the ldquoclassicrdquo broadcast industry to set up and maintain a direct relationship with their TV-viewers and radio-listeners. Until recently, a broadcaster had a one way connection with its customers, namely from the broadcaster, over the TV and radio distribution channel to the physical TV screen or radio set. Interaction was only possible after implementing and deploying expensive and hard-to-develop software on the set-top box. By employing web technology intelligently, a broadcaster can now more easily connect to its consumers and build a direct relationship. In this paper, we will discuss how to set up such a system and what the particular needs are in a broadcast context. We will use the second screen to collect data and enrich it in order to become beneficial information for the broadcasters and the advertisers.As the consumer is becoming digital - i.e. he has personal mobile and always internet-connected devices allowing him to create a digital footprint anytime, anywhere - new opportunities arise for the ldquoclassicrdquo broadcast industry to set up and maintain a direct relationship with their TV-viewers and radio-listeners. Until recently, a broadcaster had a one way connection with its customers, namely from the broadcaster, over the TV and radio distribution channel to the physical TV screen or radio set. Interaction was only possible after implementing and deploying expensive and hard-to-develop software on the set-top box. By employing web technology intelligently, a broadcaster can now more easily connect to its consumers and build a direct relationship. In this paper, we will discuss how to set up such a system and what the particular needs are in a broadcast context. We will use the second screen to collect data and enrich it in order to become beneficial information for the broadcasters and the advertisers.C